研究内容
- 食品益生菌或菌群的筛选、改造和应用
- 细胞代谢、细胞衰老的机理性研究
论文
- 1. Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub. W. Tan#, S. Cheng#, Y. Li#, N. Lu, J. Sun, G. Tang, Y. Yang, K. Cai, X. Ou, X. Gao, G-P. Zhao, W.S. Childers, W. Zhao*. Nature Communications 13:7181. 2022
- 2. A CRISPR-SpCas9M-reporting system for efficient and rapid genome editing in Caulobacter crescentus. J. Sun#, X. Yu#, G. Tang, M. Chen, Y. Zheng, Y. Hu, Q. Li, X. Li, N. Li, Z. Li, Y. Li, N. Lu, W. Tan, Y. Yang, X. Lyu, G. Zhao, H. Wang, L. Dai, G-P. Zhao, L. Ai*, W. Zhao*. Nucleic Acids Research 53(8). 2025
- 3. Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor. P. Li, H. Zhang, G-P. Zhao*, W. Zhao*. Nucleic Acids Research 48(9):4902-4914. 2020
- 4. Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. J. Shi#,*, L. Wang#, A. Wen#, F. Wang#, Y. Zhang, L. Yu, F. Li, Y. Jin, Z. Feng, J. Li, Y. Yang, F. Gao, Y. Zhang, Y. Feng*, S. Wang*, W. Zhao*, W. Lin*. Nucleic Acids Research 50(19):11359–11373. 2022
- 5. Targeted genomic editing of human gut Bacteroides species based on CRISPR-associated transposases. Y. Hu#, Q. Li#, Y. Li, Y. Zeng, L. Zheng, J. Shen, X. Gao, G-P. Zhao, W. Zhao*, L. Dai*. Cell Systems 17, 101650. 2026
- 6. Scaffold-scaffold interaction facilitates cell polarity development in Caulobacter crescentus. N. Lu#, S.W. Duvall#, G. Zhao, K.A. Kowallis, C. Zhang, W. Tan, J. Sun, H.N. Petitjean, D.T. Tomares, G-P. Zhao, W.S. Childers*, W. Zhao*. mBio 14 (2), e03218-22, 2023
- 7. Global insights into lysine acylomes reveal crosstalk between lysine acetylation and succinylation in Streptomyces coelicolor metabolic pathways. Y. Yang#, H. Zhang#, Z. Guo, S. Zou, F. Long, J. Wu, P. Li*, G-P. Zhao*, W. Zhao*. Molecular & Cellular Proteomics 20, 100148. 2021
- 8. ScCobB2-mediated lysine desuccinylation regulates protein biosynthesis and carbon metabolism in Streptomyces coelicolor. H. Zhang, P. Li, S. X. Ren, Z. Y. Chen, G-P. Zhao*, W. Zhao*. Molecular & Cellular Proteomics 18(10):2003-2017. 2019
- 9. Recent advances in the synthesis and application of biomolecular condensates. Z. Li, W. Tan, G-P. Zhao, X. Zeng*, W. Zhao*. Journal of Biological Chemistry 108188, 2025
- 10. Zymograph profiling reveals a divergent evolution of sirtuin that may originate from Class III enzymes. Y. Yang#, S. Zou#, K. Cai, N. Li, Z. Li, W. Tan, W. Lin*, GP. Zhao*, W. Zhao*. Journal of Biological Chemistry 105339. 2023
- 11. Cyclic AMP inhibits the activity and promotes the acetylation of acetyl-CoA synthetase through competitive binding to the ATP/AMP pocket. X.B. Han#, L.Q. Shen#, Q. Wang, X. Cen, J. Wang, M. Wu, P. Li, W. Zhao*, Y. Zhang* and G-P. Zhao*. Journal of Biological Chemistry 292:1374-1384. 2017
- 12. RT-RPA-Cas12a-based assay facilitates the discrimination of SARS-CoV-2 variants of concern. G. Tang#, Z. Zhang#, W. Tan#, F. Long, J. Sun, Y. Li, S. Zou, Y. Yang, K. Cai, S. Li, Z. Wang, J. Liu, G. Mao, Y. Ma, G-P. Zhao*, Z-G. Tian*, W. Zhao*. Sensors and Actuators B: Chemical 381, 133433, 2023
- 13. Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis. L. Xu#, H. Huang#, W. Wei#, Y. Zhong, B. Tang, H. Yuan, L. Zhu, W. Huang, M. Ge, S. Yang, H. Zheng, W. Jiang*, D. Chen*, G-P. Zhao*, W. Zhao*. BMC Genomics 15:363. 2014
- 14. Spatiotemporal Control of Liquid–Liquid Phase Separation for Advanced Biomanufacturing. Y. Li#, C. Zeng#, X. Lyu, W. Tan, W. Zhao*. ACS Synthetic Biology 14 (11), 4255-4265. 2025
- 15. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. W. Zhao#, Y. Zhong#, H. Yuan#, J. Wang#, H. Zheng, Y. Wang, X. Cen, F. Xu, J. Bai, X. Han, G. Lu, Y. Zhu, Z. Shao, H. Yan, C. Li, N. Peng, Z. Zhang, Y. Zhang, W. Lin, Y. Fan, Z. Qin, Y. Hu, B. Zhu, S. Wang*, X. Ding*, G-P. Zhao*. Cell Research 20:1096-1108. 2010
- 16. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Q. Wang, Y. Zhang, C. Yang, H. Xiong, Y. Lin, J. Yao, H. Li, L. Xie, W. Zhao, Y. Yao, Z. B. Ning, R. Zeng, Y. Xiong, K. L. Guan, S. Zhao*, and G-P. Zhao*. Science 327:1004-1007. 2010.
- 17. Unraveling Enzyme-Substrate Dynamics in Protein Acylation and Disease Implications. S. Cheng, T. Liu, J. Xing, G. Zhang, L. Zhang*, W. Zhao*. Frontiers in Molecular Biosciences 13, 1842734. 2026